GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs3772130 | 1 | rs3772128 | chr3:121345094 | IQCB1 | chr3:121488610-121553926:- | 0.48 | 4.47 | 2.2E-5 | Cognitive performance |
| THYM | cis | rs3772130 | 1 | rs3772130 | chr3:121344140 | IQCB1 | chr3:121488610-121553926:- | 0.48 | 4.47 | 2.2E-5 | Cognitive performance |
| THYM | cis | rs9815354 | 1 | rs3774372 | chr3:41877414 | ULK4 | chr3:41288091-42003660:- | 0.94 | 9.49 | 2.06E-15 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs3774808 | chr3:48481647 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.23 | 5.28E-5 | Longevity |
| THYM | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.62 | 1.9E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs3782130 | chr12:58161898 | TSFM | chr12:58176536-58191367:+ | -0.27 | -4.75 | 7.08E-6 | Multiple sclerosis |
| THYM | cis | rs10416265 | 1 | rs3786933 | chr19:33602881 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.33 | 3.69E-5 | Bone properties (heel) |
| THYM | cis | rs911119 | 1 | rs3787498 | chr20:23616781 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.51 | 1.87E-5 | Chronic kidney disease |
| THYM | cis | rs911119 | 1 | rs3787499 | chr20:23616807 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.51 | 1.87E-5 | Chronic kidney disease |
| THYM | cis | rs60843830 | 1 | rs3791220 | chr2:227066 | SH3YL1 | chr2:218138-264810:- | -0.31 | -4.56 | 1.52E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs3791221 | chr2:226933 | SH3YL1 | chr2:218138-264810:- | -0.31 | -4.56 | 1.52E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs3791223 | chr2:222336 | SH3YL1 | chr2:218138-264810:- | -0.3 | -4.42 | 2.59E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs3791224 | chr2:221981 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.62 | 1.2E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs2130392 | 1 | rs3796689 | chr4:185649866 | MLF1IP | chr4:185615220-185655286:- | -0.35 | -8.02 | 2.79E-12 | Kawasaki disease |
| THYM | cis | rs6932590 | 1 | rs3800316 | chr6:27256102 | LOC100270746 | chr6:26987146-26988085:- | 0.4 | 5.14 | 1.46E-6 | Schizophrenia |